Multifunctional POSS-based nanoparticles functionalized with silver, SPIONs, and rhamnolipid for antibacterial applications
Nano-engineered materials, particularly those featuring bio-based surface modifications, are emerging as effective tools in combating bacterial infections. In this study, polyhedral oligomeric silsesquioxane (POSS) nanoparticles were functionalized with silver nanoparticles (Ag), superparamagnetic iron oxide nanoparticles (SPIONs), and the biosurfactant rhamnolipid (RL)—either individually or in combination—to evaluate their antibacterial and antibiofilm activities against Staphylococcus aureus (S. […]
Ultrafast Green Synthesis of Superparamagnetic Hybrid Nanoparticle for Advanced Applications
The integration of superparamagnetic iron oxide nanoparticles (SPIONs) into functional hybrid nanostructures remains a challenge, particularly in preserving their magnetic properties within composite frameworks. Herein, we present a rapid and environmentally friendly synthesis strategy for SPION- decorated polyhedral oligomeric silsesquioxane (POSS) nanoparticles. The process involves UV- induced polymerization to form POSS nanoparticles, followed by in […]
Recent Developments and Applications in Two-Dimensional and Three-Dimensional Cell Culture Models
The limited availability of resources written in Turkish in our field negatively affects both academic research and sectoral developments. In an effort to partially address this gap, the article we have written aims to serve as a guide for both researchers interested in the subject and practitioners. 📄For readers interested in reviewing the article: 👉 […]
Assessment of Anticancer Effects of Aloe vera on 3D Liver Tumor Spheroids in a Microfluidic Platform
🌿 Proud to share our latest publication in Biotechnology and Bioengineering! “Assessment of Anticancer Effects of Aloe vera on 3D Liver Tumor Spheroids in a Microfluidic Platform” 📅 Published: June 20, 2025 🔗 Read the full article here: https://lnkd.in/d74ED44Q In this study, we explored the anticancer potential of Aloe vera using a microfluidic system that […]
35th Anniversary World Congress on Biosensors
🔬 As MNP Research Group, we proudly participated in the 35th Anniversary World Congress on Biosensors! It was a great opportunity to share our latest research on an international stage, where we presented three posters showcasing our innovative work. 🎓 Our Poster Presentations: 📌 Magnetic Hybrid Nanoparticle-Based Microfluidic Aptasensor for Rapid Bacteria Detection in Complex […]
Microfluidic rapid isolation and electrochemical detection of S. pneumonia via aptamer-decorated surfaces
Full Text: https://doi.org/10.1016/j.aca.2025.343726 S. pneumoniae is widely recognized as a leading cause of respiratory infections worldwide, often resulting in high mortality rates. However, the advent of microfluidic technologies has brought significant advancements, including the simplified, sensitive, cost-effective, and rapid approach to pneumococcal bacteremia detection. In this study, a microfluidic magnetic platform is presented for rapid […]
Microfluidic vs. batch synthesis of fluorescent micro/nanoparticles
Fluorescent particles play a crucial role in nanomedicine and biological applications such as imaging, diagnostic tools, drug delivery, biosensing, multimodal imaging, and theranostics. This report presents a novel synthesis method and comparative study for synthesizing fluorescent particles in microfluidic continuous and batch-type reactors. Glycidyl methacrylate (GMA) and ethylene glycol dimethyl acrylate (EGDMA) are well-known monomers […]
Aptamer decorated PDA@magnetic silica microparticles for bacteria purification
One significant constraint in the advancement of biosensors is the signal-to-noise ratio, which is adversely affected by the presence of interfering factors such as blood in the sample matrix. In the present investigation, a specific aptamer binding was chosen for its affinity, while exhibiting no binding affinity towards non-target bacterial cells. This selective binding […]
Biosensor for ATP detection via aptamer-modified PDA@ POSS nanoparticles synthesized in a microfluidic reactor
This study introduces aptamer-functionalized polyhedral oligomeric silsesquioxane (POSS) nanoparticles for adenosine triphosphate (ATP) detection where the POSS nanoparticles were synthesized in a one-step, continuous flow microfluidic reactor utilizing thermal polymerization. A microemulsion containing POSS monomers was generated in the microfluidic reactor which was designed to prevent clogging by using a continuous oil flow […]
Novel 3D-Printed Microfluidic Magnetic Platform for Rapid DNA Isolation
Click here for full text This study presents a novel miniaturized device as a 3D-printed microfluidic magnetic platform specifically designed to manipulate magnetic microparticles in a microfluidic chip for rapid deoxyribonucleic acid (DNA) isolation. The novel design enables the movement of the magnetic particles in the same or opposite directions with the flow or […]