Development of Next Generation Dynamic Cell Culture Model:
3D Microfluidic Magnetic Cell Culture
Wellcome!
MNP Research Group
The MNP research group is currently working on fluorescent micro/nanoparticle synthesis, drug discovery-toxicity testing kits for point-of-care and target delivery, antimicrobial materials, and microfluidic water treatments with two ongoing projects. The research interests focused on green synthesis techniques, hybrid particles, and 3D cell culture models. Our contributions appeared in peer-reviewed journal articles, patents, and projects. We collaborate with several universities and industrial partners around the world.
Thanks for your interest!
citation
article
Project done
Research Applications
Separation Systems
Bioprocessing and Chromatography:
• Bioseparation techniques for the purification of proteins, antibodies, and other biopharmaceuticals.
• Continuous bioprocessing methods for increased efficiency and productivity.
• Liquid Chromatography (HPLC): High-performance liquid chromatography is widely employed to separate biomolecules based on various properties.
Nanotechnology in Separation:
• Application of nanomaterials in separation processes for enhanced selectivity and efficiency.
• Nanofluidic devices for precise control in separation at the nanoscale
Cell Culture
Cell Culture Techniques:
• Monolayer Culture: Cells adhere to the substrate and form a single layer.
• 3D Culture: Mimics the in vivo environment, promoting more natural cell behavior.
• Dynamic Culture: Cells are exposed to controlled mechanical forces and shear stress.
Drug Discovery:
• Screening and testing potential drugs before moving to in vivo studies,
• Evaluate the toxicity of chemicals and drugs, reducing the need for animal testing.
Catalyst
Heterogeneous Catalysts:
• Supported Noble Metal Catalysts: Palladium (Pd), platinum (Pt), and other noble metals are supported on various materials like activated carbon for catalytic reduction of contaminants.
Biosensors
Surface-enhanced Raman scattering (SERS)
• the enhanced signals provided by nanostructured metallic surfaces
• Offers high sensitivity and specificity for detecting and identifying biological molecules
Research Interest
MNP research group
Polymer Particles
Monodisperse polymeric particles
• Microparticles from 1µm to 10µm in size with different functional groups (carboxyl, amin, hydroxyl, zwitterionic …)
Hybrid Particles
• Polymer-Metal Hybrids
• Polymer-Inorganic Nanoparticle Hybrids
• Lipid-Polymer Hybrids
Lipid Particles
• Solid lipid nanoparticles (SLNs)
• Nanostructured lipid carriers (NLCs)
• Lipid nanoparticles (LNPs)
Magnetic Particles
• Superpara magnetic iron nano oxides (SPION) particles
• Magnetic nanoparticle decorations
Metal Particles
• Gold nanoparticles
• Silver nanoparticles
Janus Particles
• Magnetic and fluorescent janus particles
Our Latest News
MNP Research Group
Biosensor for ATP detection via aptamer-modified PDA@ POSS nanoparticles synthesized in a microfluidic reactor
This study introduces aptamer-functionalized polyhedral oligomeric silsesquioxane (POSS) nanoparticles for adenosine triphosphate (ATP) detection where the POSS nanoparticles were synthesized in a one-step, continuous flow microfluidic reactor utilizing thermal polymerization. A microemulsion containing POSS monomers was generated in the microfluidic reactor which was designed to prevent clogging by…
International Women’s Day
International Women’s Day- The anniversary of the beginning of ATU as a faculty member. The kind congratulations from Dean Prof. Dr. Ahmet Beycioğlu for our new projects is truly a wonderful achievement and a source of motivation .It is a great honor to be in a position ongoing project such…
Novel 3D-Printed Microfluidic Magnetic Platform for Rapid DNA Isolation
Click here for full text This study presents a novel miniaturized device as a 3D-printed microfluidic magnetic platform specifically designed to manipulate magnetic microparticles in a microfluidic chip for rapid deoxyribonucleic acid (DNA) isolation. The novel design enables the movement of the magnetic particles in the same or opposite…